14. Behandling av ikke-kurable metastaser

Aasebø, K., Dragomir, A., Sundström, M., Mezheyeuski, A., Edqvist, P. H., Eide, G. E., Ponten, F., Pfeiffer, P., ... Sorbye, H. (2019). Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients. Cancer medicine, 8(7), 3623-3635.

Adams, R. A., Fisher, D. J., Graham, J., Seligmann, J. F., Seymour, M., Kaplan, R., Yates, E., Parmar, M., ... Maughan, T. S. (2021). Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial. Journal of Clinical Oncology, 39(33), 3693-3704.

Amado, R. G., Wolf, M., Peeters, M., Van Cutsem, E., Siena, S., Freeman, D. J., Juan, T., Sikorski, R., ... Chang, D. D. (2008). Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. Journal of Clinical Oncology, 26(10), 1626-1634.

Amstutz, U., Henricks, L. M., Offer, S. M., Barbarino, J., Schellens, J. H. M., Swen, J. J., Klein, T. E., McLeod, H. L., ... Schwab, M. (2018). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update. Clinical Pharmacology and Therapeutics, 103(2), 210-216.

André, T., Lonardi, S., Wong, K. Y. M., Lenz, H. J., Gelsomino, F., Aglietta, M., Morse, M. A., Van Cutsem, E., ... Overman, M. J. (2022). Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142. Annals of Oncology, 33(10), 1052-1060.

André, T., Shiu, K. K., Kim, T. W., Jensen, B. V., Jensen, L. H., Punt, C., Smith, D., Garcia-Carbonero, R., ... Diaz, L. A. ,. J. (2020). Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer. New England Journal of Medicine, 383(23), 2207-2218.

Aparicio, T., Bouché, O., Taieb, J., Maillard, E., Kirscher, S., Etienne, P. L., Faroux, R., Khemissa Akouz, F., ... Bedenne, L. (2018). Bevacizumab+chemotherapy versus chemotherapy alone in elderly patients with untreated metastatic colorectal cancer: a randomized phase II trial-PRODIGE 20 study results. Annals of Oncology, 29(1), 133-138.

Audisio, R. A., & Papamichael, D. (2012). Treatment of colorectal cancer in older patients. Nature Reviews: Gastroenterology & Hepatology, 9(12), 716-25.

Bekaii-Saab, T. S., Ou, F. S., Ahn, D. H., Boland, P. M., Ciombor, K. K., Heying, E. N., Dockter, T. J., Jacobs, N. L., ... Grothey, A. (2019). Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study. Lancet Oncology, 20(8), 1070-1082.

Bokemeyer, C., Bondarenko, I., Hartmann, J. T., de Braud, F., Schuch, G., Zubel, A., Celik, I., Schlichting, M., & Koralewski, P. (2011). Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Annals of Oncology, 22(7), 1535-1546.

Brulé, S. Y., Jonker, D. J., Karapetis, C. S., O'Callaghan, C. J., Moore, M. J., Wong, R., Tebbutt, N. C., Underhill, C., ... Goodwin, R. A. (2015). Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17. European Journal of Cancer, 51(11), 1405-14.

Cassidy, J., Clarke, S., Diaz-Rubio, E., Scheithauer, W., Figer, A., Wong, R., Koski, S., Lichinitser, M., ... Saltz, L. (2008). Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. Journal of Clinical Oncology, 26(12), 2006-2012.

Chibaudel, B., Maindrault-Goebel, F., Lledo, G., Mineur, L., Andre, T., Bennamoun, M., Mabro, M., Artru, P., ... de Gramont, A. (2009). Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. Journal of Clinical Oncology, 27(34), 5727-5733.

Cirocchi, R., Trastulli, S., Abraha, I., Vettoretto, N., Boselli, C., Montedori, A., Parisi, A., Noya, G., & Platell, C. (2012). Non-resection versus resection for an asymptomatic primary tumour in patients with unresectable stage IV colorectal cancer. Cochrane Database of Systematic Reviews, 8(8), CD008997.

Cohen, R., Liu, H., Fiskum, J., Adams, R., Chibaudel, B., Maughan, T. S., Van Cutsem, E., Venook, A., ... André, T. (2021). BRAF V600E Mutation in First-Line Metastatic Colorectal Cancer: An Analysis of Individual Patient Data From the ARCAD Database. Journal of the National Cancer Institute, 113(10), 1386-1395.

Colle, R., Radzik, A., Cohen, R., Pellat, A., Lopez-Tabada, D., Cachanado, M., Duval, A., Svrcek, M., ... André, T. (2021). Pseudoprogression in patients treated with immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer. European Journal of Cancer, 144, 9-16.

Cremolini, C., Loupakis, F., Masi, G., Lonardi, S., Granetto, C., Mancini, M. L., Chiara, S., Moretto, R., ... Falcone, A. (2016). FOLFOXIRI or FOLFOXIRI plus bevacizumab as first-line treatment of metastatic colorectal cancer: a propensity score-adjusted analysis from two randomized clinical trials. Annals of Oncology, 27(5), 843-9.

Cunningham, D., Lang, I., Marcuello, E., Lorusso, V., Ocvirk, J., Shin, D. B., Jonker, D., Osborne, S., ... Saunders, M. P. (2013). Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial. Lancet Oncology, 14(11), 1077-85.

de Gramont, A., Buyse, M., Abrahantes, J. C., Burzykowski, T., Quinaux, E., Cervantes, A., Figer, A., Lledo, G., ... Tournigand, C. (2007). Reintroduction of oxaliplatin is associated with improved survival in advanced colorectal cancer. Journal of Clinical Oncology, 25(22), 3224-3229.

de Gramont, A., Figer, A., Seymour, M., Homerin, M., Hmissi, A., Cassidy, J., Boni, C., Cortes-Funes, H., ... Bonetti, A. (2000). Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. Journal of Clinical Oncology, 18(16), 2938-2947.

Deenen, M. J., Meulendijks, D., Cats, A., Sechterberger, M. K., Severens, J. L., Boot, H., Smits, P. H., Rosing, H., ... Schellens, J. H. (2016). Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis. Journal of Clinical Oncology, 34(3), 227-34.

Derksen, J. W. G., Smit, K. C., May, A. M., & Punt, C. J. A. (2022). Systematic review and non-inferiority meta-analysis of randomised phase II/III trials on S-1-based therapy versus 5-fluorouracil- or capecitabine-based therapy in the treatment of patients with metastatic colorectal cancer. European Journal of Cancer, 166, 73-86.

Diaz, L. A. ,. J., Shiu, K. K., Kim, T. W., Jensen, B. V., Jensen, L. H., Punt, C., Smith, D., Garcia-Carbonero, R., ... Andre, T. (2022). Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study. Lancet Oncology, 23(5), 659-670.

Doebele, R. C., Drilon, A., Paz-Ares, L., Siena, S., Shaw, A. T., Farago, A. F., Blakely, C. M., Seto, T., ... Demetri, G. D. (2020). Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials. Lancet Oncology, 21(2), 271-282.

Douillard, J. Y., Siena, S., Cassidy, J., Tabernero, J., Burkes, R., Barugel, M., Humblet, Y., Bodoky, G., ... Gansert, J. (2010). Randomized, Phase III Trial of Panitumumab With Infusional Fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX4) Versus FOLFOX4 Alone As First-Line Treatment in Patients With Previously Untreated Metastatic Colorectal Cancer: The PRIME Study. Journal of Clinical Oncology, 28(31), 4697-4705.

Douillard, J. Y., Cunningham, D., Roth, A. D., Navarro, M., James, R. D., Karasek, P., Jandik, P., Iveson, T., ... Rougier, P. (2000). Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet, 355(9209), 1041-1047.

Douillard, J. Y., Oliner, K. S., Siena, S., Tabernero, J., Burkes, R., Barugel, M., Humblet, Y., Bodoky, G., ... Patterson, S. D. (2013). Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. New England Journal of Medicine, 369(11), 1023-34.

Ducreux, M., Malka, D., Mendiboure, J., Etienne, P. L., Texereau, P., Auby, D., Rougier, P., Gasmi, M., ... Federation Francophone de Cancerologie Digestive -05 Collaborative, G. (2011). Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial. Lancet Oncology, 12(11), 1032-44.

Falcone, A., Ricci, S., Brunetti, I., Pfanner, E., Allegrini, G., Barbara, C., Crinò, L., Benedetti, G., ... Masi, G. (2007). Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. Journal of Clinical Oncology, 25(13), 1670-6.

Faron, M., Pignon, J. P., Malka, D., Bourredjem, A., Douillard, J. Y., Adenis, A., Elias, D., Bouche, O., & Ducreux, M. (2015). Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials. European Journal of Cancer, 51(2), 166-76.

Fuchs, C. S., Marshall, J., Mitchell, E., Wierzbicki, R., Ganju, V., Jeffery, M., Schulz, J., Richards, D., ... Barrueco, J. (2007). Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. Journal of Clinical Oncology, 25(30), 4779-86.

Giantonio, B. J., Catalano, P. J., Meropol, N. J., O'Dwyer, P. J., Mitchell, E. P., Alberts, S. R., Schwartz, M. A., Benson, A. B. ,. 3., & Eastern Cooperative Oncology Group Study, E. (2007). Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. Journal of Clinical Oncology, 25(12), 1539-44.

Glimelius, B., Ristamaki, R., Kjaer, M., Pfeiffer, P., Skovsgaard, T., Tveit, K. M., Linne, T., Frodin, J. E., ... Pyrhonen, S. (2002). Irinotecan combined with bolus 5-fluorouracil and folinic acid Nordic schedule as first-line therapy in advanced colorectal cancer. Annals of Oncology, 13(12), 1868-1873.

Glimelius, B., Sorbye, H., Balteskard, L., Bystrom, P., Pfeiffer, P., Tveit, K., Heikkila, R., Keldsen, N., ... Berglund, A. (2008). A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer. Annals of Oncology, 19(5), 909-14.

Glimelius, B., & Cavalli-Bjorkman, N. (2012). Metastatic colorectal cancer: Current treatment and future options for improved survival Medical approach - present status. Scandinavian Journal of Gastroenterology, 47(3), 296-314.

Gramont Lesparre, A. H., Chibaudel, B., Bourges, O., Perez-Staub, N., Tournigand, C., Maindrault-Goebel, F., André, T., Larsen, A. K., ... Louvet, C. (2009). Definition of oxaliplatin sensitivity in patients with advanced colorectal cancer previously treated with oxaliplatin-based therapy. [Foredrag på 2009 ASCO Annual Meeting]. Journal of Clinical Oncology, 27(15 Suppl), 4024.

Grothey, A., Van Cutsem, E., Sobrero, A., Siena, S., Falcone, A., Ychou, M., Humblet, Y., Bouche, O., ... Laurent, D. (2013). Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet, 381(9863), 303-12.

Grothey, A. (2010). Reintroduction of oxaliplatin: a viable approach to the long-term management of metastatic colorectal cancer. Oncology, 79(5-6), 389-99.

Hamfjord, J., Myklebust, T., Larsen, I. K., Kure, E. H., Glimelius, B., Guren, T. K., Tveit, K. M., & Guren, M. G. (2022). Survival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study. Cancer Epidemiology, Biomarkers and Prevention, 31(2), 342-351.

Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., ... Kabbinavar, F. (2004). Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. New England Journal of Medicine, 350(23), 2335-42.

Kabbinavar, F. F., Hambleton, J., Mass, R. D., Hurwitz, H. I., Bergsland, E., & Sarkar, S. (2005). Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. Journal of Clinical Oncology, 23(16), 3706-12.

Kanemitsu, Y., Shitara, K., Mizusawa, J., Hamaguchi, T., Shida, D., Komori, K., Ikeda, S., Ojima, H., ... Fukuda, H. (2021). Primary Tumor Resection Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastases (JCOG1007; iPACS): A Randomized Clinical Trial. Journal of Clinical Oncology, 39(10), 1098-1107.

Karapetis, C. S., Khambata-Ford, S., Jonker, D. J., O'Callaghan, C. J., Tu, D., Tebbutt, N. C., Simes, R. J., Chalchal, H., ... Zalcberg, J. R. (2008). K-ras mutations and benefit from cetuximab in advanced colorectal cancer. New England Journal of Medicine, 359(17), 1757-65.

Koopman, M., Antonini, N. F., Douma, J., Wals, J., Honkoop, A. H., Erdkamp, F. L., de Jong, R. S., Rodenburg, C. J., ... Punt, C. J. (2007). Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet, 370(9582), 135-142.

Kopetz, S., Grothey, A., Yaeger, R., Van Cutsem, E., Desai, J., Yoshino, T., Wasan, H., Ciardiello, F., ... Tabernero, J. (2019). Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer. New England Journal of Medicine, 381(17), 1632-1643.

Ku, G. Y., Haaland, B. A., & de Lima Lopes, G. ,. J. (2012). Cetuximab in the first-line treatment of K-ras wild-type metastatic colorectal cancer: the choice and schedule of fluoropyrimidine matters. Cancer Chemotherapy and Pharmacology, 70(2), 231-8.

Larsen, I. K. (2022). Cancer in Norway 2021: cancer incidence, mortality, survival and prevalence in Norway. Cancer Registry of Norway.

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., ... Diaz, L. A. ,. J. (2015). PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. New England Journal of Medicine, 372(26), 2509-20.

Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., ... Diaz, L. A. ,. J. (2017). Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science, 357(6349), 409-413.

Leighl, N. B., Bennouna, J., Yi, J., Moore, N., Hambleton, J., & Hurwitz, H. (2011). Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study. British Journal of Cancer, 104(3), 413-8.

Lenz, H. J., Van Cutsem, E., Luisa Limon, M., Wong, K. Y. M., Hendlisz, A., Aglietta, M., García-Alfonso, P., Neyns, B., ... Lonardi, S. (2022). First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study. Journal of Clinical Oncology, 40(2), 161-170.

Leo, S., Accettura, C., Gnoni, A., Licchetta, A., Giampaglia, M., Mauro, A., Saracino, V., & Carr, B. I. (2013). Systemic treatment of gastrointestinal cancer in elderly patients. Journal of Gastrointestinal Cancer, 44(1), 22-32.

Lievre, A., Bachet, J. B., Boige, V., Cayre, A., Le Corre, D., Buc, E., Ychou, M., Bouche, O., ... Laurent-Puig, P. (2008). KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. Journal of Clinical Oncology, 26(3), 374-379.

Loupakis, F., Cremolini, C., Salvatore, L., Masi, G., Sensi, E., Schirripa, M., Michelucci, A., Pfanner, E., ... Falcone, A. (2014). FOLFOXIRI plus bevacizumab as first-line treatment in BRAF mutant metastatic colorectal cancer. European Journal of Cancer, 50(1), 57-63.

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Maroney, S., de Paz, C. C., Reeves, M. E., Garberoglio, C., Raskin, E., Senthil, M., Namm, J. P., & Solomon, N. (2018). Benefit of Surgical Resection of the Primary Tumor in Patients Undergoing Chemotherapy for Stage IV Colorectal Cancer with Unresected Metastasis. Journal of Gastrointestinal Surgery, 22(3), 460-466.

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Mayer, R. J., Van Cutsem, E., Falcone, A., Yoshino, T., Garcia-Carbonero, R., Mizunuma, N., Yamazaki, K., Shimada, Y., ... Ohtsu, A. (2015). Randomized trial of TAS-102 for refractory metastatic colorectal cancer. New England Journal of Medicine, 372(20), 1909-19.

Meric-Bernstam, F., Hurwitz, H., Raghav, K. P. S., McWilliams, R. R., Fakih, M., VanderWalde, A., Swanton, C., Kurzrock, R., ... Hainsworth, J. (2019). Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study. Lancet Oncology, 20(4), 518-530.

Meulendijks, D., Henricks, L. M., Sonke, G. S., Deenen, M. J., Froehlich, T. K., Amstutz, U., Largiadèr, C. R., Jennings, B. A., ... Schellens, J. H. (2015). Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data. Lancet Oncology, 16(16), 1639-50.

Modest, D. P., Martens, U. M., Riera-Knorrenschild, J., Greeve, J., Florschütz, A., Wessendorf, S., Ettrich, T., Kanzler, S., ... Geissler, M. (2019). FOLFOXIRI Plus Panitumumab As First-Line Treatment of RAS Wild-Type Metastatic Colorectal Cancer: The Randomized, Open-Label, Phase II VOLFI Study (AIO KRK0109). Journal of Clinical Oncology, 37(35), 3401-3411.

Nitsche, U., Stöß, C., Stecher, L., Wilhelm, D., Friess, H., & Ceyhan, G. O. (2018). Meta-analysis of outcomes following resection of the primary tumour in patients presenting with metastatic colorectal cancer. British Journal of Surgery, 105(7), 784-796.

Osterlund, P., Kinos, S., Pfeiffer, P., Salminen, T., Kwakman, J. J. M., Frödin, J. E., Shah, C. H., Sorbye, H., ... Glimelius, B. (2022). Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours: a multicentre retrospective observational cohort study. ESMO Open, 7(3), 100427.

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Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H. J., Morse, M. A., Desai, J., Hill, A., ... Andre, T. (2017). Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncology, 18(9), 1182-1191.

Parseghian, C. M., Napolitano, S., Loree, J. M., & Kopetz, S. (2019). Mechanisms of Innate and Acquired Resistance to Anti-EGFR Therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies. Clinical Cancer Research, 25(23), 6899-6908.

Pfeiffer, P., Yilmaz, M., Möller, S., Zitnjak, D., Krogh, M., Petersen, L. N., Poulsen, L., Winther, S. B., ... Qvortrup, C. (2020). TAS-102 with or without bevacizumab in patients with chemorefractory metastatic colorectal cancer: an investigator-initiated, open-label, randomised, phase 2 trial. Lancet Oncology, 21(3), 412-420.

Pietrantonio, F., Petrelli, F., Coinu, A., Di Bartolomeo, M., Borgonovo, K., Maggi, C., Cabiddu, M., Iacovelli, R., ... Barni, S. (2015). Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: a meta-analysis. European Journal of Cancer, 51(5), 587-94.

Pietrantonio, F., Cremolini, C., Aprile, G., Lonardi, S., Orlandi, A., Mennitto, A., Berenato, R., Antoniotti, C., ... de Braud, F. (2015). Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope. Oncologist, 20(11), 1261-5.

Poultsides, G. A., Servais, E. L., Saltz, L. B., Patil, S., Kemeny, N. E., Guillem, J. G., Weiser, M., Temple, L. K., ... Paty, P. B. (2009). Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment. Journal of Clinical Oncology, 27(20), 3379-3384.

Prager, G. W., Taieb, J., Fakih, M., Ciardiello, F., Van Cutsem, E., Elez, E., Cruz, F. M., Wyrwicz, L., ... Tabernero, J. (2023). Trifluridine-Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer. New England Journal of Medicine, 388(18), 1657-1667.

Price, T. J., Peeters, M., Kim, T. W., Li, J., Cascinu, S., Ruff, P., Suresh, A. S., Thomas, A., ... Sidhu, R. (2014). Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study. Lancet Oncology, 15(6), 569-79.

Raghav, K., Loree, J. M., Morris, J. S., Overman, M. J., Yu, R., Meric-Bernstam, F., Menter, D., Korphaisarn, K., ... Kopetz, S. (2019). Validation of HER2 Amplification as a Predictive Biomarker for Anti–Epidermal Growth Factor Receptor Antibody Therapy in Metastatic Colorectal Cancer. JCO Precision Oncology, (3), 1-13.

Rahbari, N. N., Biondo, S., Feißt, M., Bruckner, T., Rossion, I., Luntz, S., Bork, U., Büchler, M. W., ... Groups, C. T. (2022). Randomized clinical trial on resection of the primary tumor versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases. Journal of Clinical Oncology, 40(17_suppl), LBA3507-LBA3507.

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Salvatore, L., Bria, E., Sperduti, I., Hinke, A., Hegewisch-Becker, S., Aparicio, T., Le Malicot, K., Boige, V., ... Arnold, D. (2021). Bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: A meta-analysis of individual patients' data from 3 phase III studies. Cancer Treatment Reviews, 97, 102202.

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